Relationship between Plasma Concentrations of Interleukin-10 and Thrombocytopenia in Chickenpox Patients

Document Type : Original Article

Authors

1 Department of Medicine, Infectious Disease Hospital, Ministry of Health, Kuwait

2 Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Abstract

Background and study aim: Chickenpox is highly infectious, self-limiting disease, caused by varicella-zoster virus. Thrombocytopenia frequently complicates chickenpox. This study was conducted to assess the correlation between serum interleukin 10 levels and thrombocytopenia in adult chickenpox patients.
Patients and Methods: Fifty patients of chickenpox complicated by thrombocytopenia were included in this study as a patient group. Fifty patients of chickenpox with normal platelet of comparable age, race and gender were identified as a control group. All patients were diagnosed by clinical picture of chickenpox and by presence of varicella - zoster virus immunoglobulin M (VZV IgM) in the patient blood. Estimation of complete blood count, kidney function tests, liver function tests, fasting blood sugar, and levels of cytokines IL-10 and TNF-α were done in both groups on the day of admission and day of discharge.
Results: At time of admission, IL-10 levels were significantly higher in patients group than in control group, while TNF-α level were not significantly different between the two groups. At time of discharge, we observed a significant decline in IL-10 levels in the patients group as compared with time of admission. A negative correlation between IL-10 levels and platelet count was observed while no correlation was found between TNF-α and platelet count.
Conclusion: IL-10 level could play an important role in development of thrombocytopenia in patients with chickenpox.
  
 

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Afro-Egyptian Journal of Infectious and Endemic Diseases
Volume 6, Issue 3
September 2016
Pages 128-133

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