Al-Fadhli, M., Saraya, M. (2016). Relationship between Plasma Concentrations of Interleukin-10 and Thrombocytopenia in Chickenpox Patients. Afro-Egyptian Journal of Infectious and Endemic Diseases, 6(3), 128-133. doi: 10.21608/aeji.2016.9956
Mariam Al-Fadhli; Mohammad Ahmed Saraya. "Relationship between Plasma Concentrations of Interleukin-10 and Thrombocytopenia in Chickenpox Patients". Afro-Egyptian Journal of Infectious and Endemic Diseases, 6, 3, 2016, 128-133. doi: 10.21608/aeji.2016.9956
Al-Fadhli, M., Saraya, M. (2016). 'Relationship between Plasma Concentrations of Interleukin-10 and Thrombocytopenia in Chickenpox Patients', Afro-Egyptian Journal of Infectious and Endemic Diseases, 6(3), pp. 128-133. doi: 10.21608/aeji.2016.9956
Al-Fadhli, M., Saraya, M. Relationship between Plasma Concentrations of Interleukin-10 and Thrombocytopenia in Chickenpox Patients. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2016; 6(3): 128-133. doi: 10.21608/aeji.2016.9956
Relationship between Plasma Concentrations of Interleukin-10 and Thrombocytopenia in Chickenpox Patients
1Department of Medicine, Infectious Disease Hospital, Ministry of Health, Kuwait
2Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abstract
Background and study aim: Chickenpox is highly infectious, self-limiting disease, caused by varicella-zoster virus. Thrombocytopenia frequently complicates chickenpox. This study was conducted to assess the correlation between serum interleukin 10 levels and thrombocytopenia in adult chickenpox patients. Patients and Methods: Fifty patients of chickenpox complicated by thrombocytopenia were included in this study as a patient group. Fifty patients of chickenpox with normal platelet of comparable age, race and gender were identified as a control group. All patients were diagnosed by clinical picture of chickenpox and by presence of varicella - zoster virus immunoglobulin M (VZV IgM) in the patient blood. Estimation of complete blood count, kidney function tests, liver function tests, fasting blood sugar, and levels of cytokines IL-10 and TNF-α were done in both groups on the day of admission and day of discharge. Results: At time of admission, IL-10 levels were significantly higher in patients group than in control group, while TNF-α level were not significantly different between the two groups. At time of discharge, we observed a significant decline in IL-10 levels in the patients group as compared with time of admission. A negative correlation between IL-10 levels and platelet count was observed while no correlation was found between TNF-α and platelet count. Conclusion: IL-10 level could play an important role in development of thrombocytopenia in patients with chickenpox.
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