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Afro-Egyptian Journal of Infectious and Endemic Diseases
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Galal, S., Raafat, N. (2016). Monocyte Chemoattractant Protein-1 as a Diagnostic Marker for Detection of Hepatocellular Carcinoma in Egypt. Afro-Egyptian Journal of Infectious and Endemic Diseases, 6(2), 75-81. doi: 10.21608/aeji.2016.9670
Sherif M Galal; Nermin Raafat. "Monocyte Chemoattractant Protein-1 as a Diagnostic Marker for Detection of Hepatocellular Carcinoma in Egypt". Afro-Egyptian Journal of Infectious and Endemic Diseases, 6, 2, 2016, 75-81. doi: 10.21608/aeji.2016.9670
Galal, S., Raafat, N. (2016). 'Monocyte Chemoattractant Protein-1 as a Diagnostic Marker for Detection of Hepatocellular Carcinoma in Egypt', Afro-Egyptian Journal of Infectious and Endemic Diseases, 6(2), pp. 75-81. doi: 10.21608/aeji.2016.9670
Galal, S., Raafat, N. Monocyte Chemoattractant Protein-1 as a Diagnostic Marker for Detection of Hepatocellular Carcinoma in Egypt. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2016; 6(2): 75-81. doi: 10.21608/aeji.2016.9670

Monocyte Chemoattractant Protein-1 as a Diagnostic Marker for Detection of Hepatocellular Carcinoma in Egypt

Article 1, Volume 6, Issue 2, June 2016, Page 75-81  XML PDF (431.96 K)
Document Type: Original Article
DOI: 10.21608/aeji.2016.9670
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Authors
Sherif M Galal email 1; Nermin Raafat2
1Departments of Tropical Medicine, Faculty of Medicine, Zagazig University, Egypt
2Departments of Medical Biochemistry, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Background and study aim: Hepatocellullar carcinoma (HCC) is usually diagnosed at advanced stage resulting in limited therapeutic options and poor prognosis. The role of alpha-fetoprotein (AFP) in the diagnosis of HCC is controversial. Here, we investigated the role of Monocyte Chemoattractant Protein -1 (MCP-1), a serum biomarker, alone or in combination with AFP for detection of HCC.
Patients and Methods: 116 patients with liver cirrhosis were included. The patients were divided into 2 groups: HCC group included 58 patients with HCC and non-HCC patients as a control group included 58 patients with no evidence of hepatic focal masses. Routine laboratory investigations, AFP, MCP-1, pelvi-abdominal ultrasonography (US) and triphasic computed tomography (CT) scan were performed in all patients. 
Results: It was found that MCP-1 at a cut-off value >0.390 ng/ml has a sensitivity of 75.8% and specificity of 88.3% with AUROC 0.916; But AFP at a cut-off value >20 ng/ml has a sensitivity of 86.5% and specificity of 96.4% with AUROC 0.924, while combined (AFP+ MCP-1) at a cut-off value >23.390 ng/ml has a higher sensitivity (96.5%) specificity of 100% with AUROC 0.995.
Conclusion: Monocyte Chemoattractant Protein-1 (MCP-1) can be identified as an adjuvant biomarker for HCC detection. Combined (AFP+MCP-1) showed higher diagnostic ability than MCP-1 alone or AFP alone in HCC detection.
Keywords
HCC; AFP; MCP-1
Main Subjects
Hepatology
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