Abd Elbaser, E., Abdelkader, A., Afifi, S. (2020). IL-1α and TGF-β1 as non-Invasive Liver Fibrosis Markers of Chronic Liver Injury among Chronic Liver Diseases Patients in Sharkia Governorate, Egypt. Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(2), 108-113. doi: 10.21608/aeji.2020.23397.1050
Elsayed Saad Abd Elbaser; Abeer Hussein Abdelkader; Samir Abdel-Azim Afifi. "IL-1α and TGF-β1 as non-Invasive Liver Fibrosis Markers of Chronic Liver Injury among Chronic Liver Diseases Patients in Sharkia Governorate, Egypt". Afro-Egyptian Journal of Infectious and Endemic Diseases, 10, 2, 2020, 108-113. doi: 10.21608/aeji.2020.23397.1050
Abd Elbaser, E., Abdelkader, A., Afifi, S. (2020). 'IL-1α and TGF-β1 as non-Invasive Liver Fibrosis Markers of Chronic Liver Injury among Chronic Liver Diseases Patients in Sharkia Governorate, Egypt', Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(2), pp. 108-113. doi: 10.21608/aeji.2020.23397.1050
Abd Elbaser, E., Abdelkader, A., Afifi, S. IL-1α and TGF-β1 as non-Invasive Liver Fibrosis Markers of Chronic Liver Injury among Chronic Liver Diseases Patients in Sharkia Governorate, Egypt. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2020; 10(2): 108-113. doi: 10.21608/aeji.2020.23397.1050
IL-1α and TGF-β1 as non-Invasive Liver Fibrosis Markers of Chronic Liver Injury among Chronic Liver Diseases Patients in Sharkia Governorate, Egypt
1Tropical Medicine Department, Faculty of Medicine, Zagazig University,Egypt.
2Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Background and study aim: Proper assessment of liver fibrosis and cirrhosis by non- invasive procedures are needed before appropriate management. This study aimed at detecting the role of IL-1α and TGF-β1as non-invasive liver fibrosis markers in chronic liver diseases. Patients and methods: The subjects included in this study were divided into 4 groups. Group1: 15 chronic HCV patients, group 2: 15 HCC patients, group 3: 15 patients with NAFLD, group 4: 15 healthy control subjects. Serum IL-1α and TGF-β1 measured by ELISA to patients and control groups with calculation of FIB-4 and APRI score. Results: IL-1α and TGF-β1 were significantly high in all hepatic patients compared to control group. The highest level of serum TGF-β1 was in HCC patients. There was a positive correlation between serum IL-1α and ALT, AST, ALP and HCV RNA by PCR. There was a negative correlation between IL-1α and TGF-β1. There was a highly significant positive correlation between TGF-β1 and FIB4, APRI score, ALP and AFP. Conclusion: Chronic liver diseases including HCV, HCC and NAFLD were associated with higher levels of IL-1α and TGF-β1 than healthy subjects.
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