• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Afro-Egyptian Journal of Infectious and Endemic Diseases
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 13 (2023)
Volume Volume 12 (2022)
Volume Volume 11 (2021)
Volume Volume 10 (2020)
Volume Volume 9 (2019)
Volume Volume 8 (2018)
Volume Volume 7 (2017)
Volume Volume 6 (2016)
Volume Volume 5 (2015)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 4 (2014)
Volume Volume 3 (2013)
Volume Volume 2 (2012)
Volume Volume 1 (2011)
Abd El-Salam, F., Abd El-Raouf, H., El Shinawy, S., Mostafa, M. (2015). Insulin Resistance as Predictor for Esophageal Varices in Hepatitis C Virus Cirrhosis. Afro-Egyptian Journal of Infectious and Endemic Diseases, 5(3), 152-159. doi: 10.21608/aeji.2015.17824
Fatma Mohamed Abd El-Salam; Hatem Abd El-Raouf; Salama Mohamed El Shinawy; Mohamed Shawky Mostafa. "Insulin Resistance as Predictor for Esophageal Varices in Hepatitis C Virus Cirrhosis". Afro-Egyptian Journal of Infectious and Endemic Diseases, 5, 3, 2015, 152-159. doi: 10.21608/aeji.2015.17824
Abd El-Salam, F., Abd El-Raouf, H., El Shinawy, S., Mostafa, M. (2015). 'Insulin Resistance as Predictor for Esophageal Varices in Hepatitis C Virus Cirrhosis', Afro-Egyptian Journal of Infectious and Endemic Diseases, 5(3), pp. 152-159. doi: 10.21608/aeji.2015.17824
Abd El-Salam, F., Abd El-Raouf, H., El Shinawy, S., Mostafa, M. Insulin Resistance as Predictor for Esophageal Varices in Hepatitis C Virus Cirrhosis. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2015; 5(3): 152-159. doi: 10.21608/aeji.2015.17824

Insulin Resistance as Predictor for Esophageal Varices in Hepatitis C Virus Cirrhosis

Article 3, Volume 5, Issue 3, September 2015, Page 152-159  XML PDF (297.04 K)
Document Type: Original Article
DOI: 10.21608/aeji.2015.17824
Authors
Fatma Mohamed Abd El-Salam1; Hatem Abd El-Raouf1; Salama Mohamed El Shinawy2; Mohamed Shawky Mostafa3
1Hepatology, Gastroenterology and Infectious Diseases Department, Faculty of Medicine, Benha University,Benha,Egypt.
2Clinical pathology Department, Shebein EL-Kom Teaching hospital, Shebein EL-Kom, Egypt.
3Hepatology, Gastroenterology and Infectious Diseases Department , Shebein El-Kom Teaching Hospital, Shebein El-Kom,Egypt
Abstract
Background and study aim :Portal hypertension is one of the most important complications of liver cirrhosis. Endoscopic screening of all patients with liver cirrhosis would result in a large number of unnecessary additional burden to endoscopic units. This study is designed to assess insulin resistance in cirrhotic patients due to hepatitis C infection as non invasive parameter for esophageal varices. .
Patients and Methods: This study was conducted on 50 cirrhotic patients (Child A) post hepatitis C who attended the Hepatology Department and outpatient clinic at Shebein El Kom Teaching Hospital. All the patients were evaluated by thorough history ,clinical examination, biochemical parameters ,metabolic features, including insulin resistance by the homeostasis model assessment (HOMA), ultrasonongraphy , liver biopsy and upper gastrointestinal endoscopy to search for esophageal varices.
Results: EVs (esophageal varices) were detected in 18 of 50 patients. By multivariate analysis ,the presence of EVs was independently associated with a low platelet count/spleen diameter ratio (562.75 + 99.16) , a high HOMA-IR score (5.49 + 0.754), high body mass index , low hemoglobin, low albumin, high alanine aminotransferase and high aspartate aminotransferase.
Conclusion: Insulin resistance in patients with Hepatitis C virus cirrhosis (Child A ) measured by HOMA-IR score significantly predicts the presence esophageal varices in this patients and can be used as non-invasive parameter for predicting esophageal varices.
Keywords
Oesophageal varices; Insulin Resistance; upper gastrointestinal endoscopy
Main Subjects
Endemic medicine; Gastroenetrology; Hepatology
Statistics
Article View: 96
PDF Download: 214
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.