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El-Ghoneimy, S., Soliman, A., Azab, M., El-Gebaly, A., Abdel Monem, S. (2015). Efficacy of Using Neutrophil to Lymphocyte Ratio and Interleukin 6 as Outcome Predictors of Interventional Treatment of Hepatocellular Carcioma. Afro-Egyptian Journal of Infectious and Endemic Diseases, 5(3), 143-151. doi: 10.21608/aeji.2015.17823
Salama M El-Ghoneimy; Amira M Soliman; Mervat M Azab; Ahmed M El-Gebaly; Sameh M Abdel Monem. "Efficacy of Using Neutrophil to Lymphocyte Ratio and Interleukin 6 as Outcome Predictors of Interventional Treatment of Hepatocellular Carcioma". Afro-Egyptian Journal of Infectious and Endemic Diseases, 5, 3, 2015, 143-151. doi: 10.21608/aeji.2015.17823
El-Ghoneimy, S., Soliman, A., Azab, M., El-Gebaly, A., Abdel Monem, S. (2015). 'Efficacy of Using Neutrophil to Lymphocyte Ratio and Interleukin 6 as Outcome Predictors of Interventional Treatment of Hepatocellular Carcioma', Afro-Egyptian Journal of Infectious and Endemic Diseases, 5(3), pp. 143-151. doi: 10.21608/aeji.2015.17823
El-Ghoneimy, S., Soliman, A., Azab, M., El-Gebaly, A., Abdel Monem, S. Efficacy of Using Neutrophil to Lymphocyte Ratio and Interleukin 6 as Outcome Predictors of Interventional Treatment of Hepatocellular Carcioma. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2015; 5(3): 143-151. doi: 10.21608/aeji.2015.17823

Efficacy of Using Neutrophil to Lymphocyte Ratio and Interleukin 6 as Outcome Predictors of Interventional Treatment of Hepatocellular Carcioma

Article 2, Volume 5, Issue 3, September 2015, Page 143-151  XML PDF (268.44 K)
Document Type: Original Article
DOI: 10.21608/aeji.2015.17823
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Authors
Salama M El-Ghoneimy1; Amira M Soliman1; Mervat M Azab2; Ahmed M El-Gebaly1; Sameh M Abdel Monem1
1Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt
2Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt
Keywords
Background and study aim: Hepatocellular carcinoma (HCC) is currently the fifth most common solid tumor worldwide and the third leading cause of cancer-related death. Percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) techniques b; the first group included 72 patients whom had NLR less than 5 and the second group included 64 patients whom had NLR equal or more than 5. Patients underwent PEI or RFA. Clinical assessment; laboratory evaluation and triphasic CT studies were performed to all patients pre-treatment and at 1; 6 and 12 months post treatment. NLR and IL-6 level were performed to all patients pre treatment and at 6 months post treatment. Results: The percentage of complete ablation is highly significantly higher in group I after 1 month but; there is no significant difference between outcome of treatment after 1 year in both groups one year after treatment. Post-procedural IL-6 showed highly significantly lower levels in patients whose focal lesions remain ablated till 1 year than in tho; while NLR did not show significant difference among these groups. Post-prcedural IL-6 levels were highly significantly lower in survived than died cases; while NLR did not show significant differences between both groups at 1 year follow up. There was no significant difference in the post-procedural level of NLR or IL-6 between the group who was treated with ethanol injection and who was treated with; liver profile; hematological profile and diameter of focal HCC and also is a good predictor for short term outcome (1-6 months) and neither pre-procedural or post-procedural NLR are predictors of long term outcome or survival (1 year). Post-procedural IL-6 could be; but also for efficacy of treatment
Main Subjects
Hepatology
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