Efficacy of Using Neutrophil to Lymphocyte Ratio and Interleukin 6 as Outcome Predictors of Interventional Treatment of Hepatocellular Carcioma

Document Type : Original Article

Authors

• Salama M El-Ghoneimy ¹
• Amira M Soliman ¹
• Mervat M Azab ²
• Ahmed M El-Gebaly ¹
• Sameh M Abdel Monem ¹

¹ Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt

² Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt

Keywords

• Background and study aim: Hepatocellular carcinoma (HCC) is currently the fifth most common solid tumor worldwide and the third leading cause of cancer-related death. Percutaneous ethanol injection (PEI) and radiofrequency ablation (RFA) techniques b
• the first group included 72 patients whom had NLR less than 5 and the second group included 64 patients whom had NLR equal or more than 5. Patients underwent PEI or RFA. Clinical assessment
• laboratory evaluation and triphasic CT studies were performed to all patients pre-treatment and at 1
• 6 and 12 months post treatment. NLR and IL-6 level were performed to all patients pre treatment and at 6 months post treatment. Results: The percentage of complete ablation is highly significantly higher in group I after 1 month but
• there is no significant difference between outcome of treatment after 1 year in both groups one year after treatment. Post-procedural IL-6 showed highly significantly lower levels in patients whose focal lesions remain ablated till 1 year than in tho
• while NLR did not show significant difference among these groups. Post-prcedural IL-6 levels were highly significantly lower in survived than died cases
• while NLR did not show significant differences between both groups at 1 year follow up. There was no significant difference in the post-procedural level of NLR or IL-6 between the group who was treated with ethanol injection and who was treated with
• liver profile
• hematological profile and diameter of focal HCC and also is a good predictor for short term outcome (1-6 months) and neither pre-procedural or post-procedural NLR are predictors of long term outcome or survival (1 year). Post-procedural IL-6 could be
• but also for efficacy of treatment

Main Subjects

• Hepatology