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Khorshed, S., Fayed, A., Kamel, L., Awad, S. (2015). Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation. Afro-Egyptian Journal of Infectious and Endemic Diseases, 5(2), 102-114. doi: 10.21608/aeji.2015.17819
Soha E Khorshed; Alaa Fayed; Lamiaa Mahmoud Kamel; Shereen M Awad. "Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation". Afro-Egyptian Journal of Infectious and Endemic Diseases, 5, 2, 2015, 102-114. doi: 10.21608/aeji.2015.17819
Khorshed, S., Fayed, A., Kamel, L., Awad, S. (2015). 'Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation', Afro-Egyptian Journal of Infectious and Endemic Diseases, 5(2), pp. 102-114. doi: 10.21608/aeji.2015.17819
Khorshed, S., Fayed, A., Kamel, L., Awad, S. Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2015; 5(2): 102-114. doi: 10.21608/aeji.2015.17819

Role of Insulin Resistance and Cytokeratin 18 on the Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation

Article 7, Volume 5, Issue 2, June 2015, Page 102-114  XML PDF (516.48 K)
Document Type: Original Article
DOI: 10.21608/aeji.2015.17819
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Authors
Soha E Khorshed1; Alaa Fayed2; Lamiaa Mahmoud Kamel3; Shereen M Awad4
1Tropical Medicine Department , Faculty of Medicine, Zagazig University, Egypt
2Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine Zagazig University, Egypt
3Clinical pathology Department, Faculty of Medicine Zagazig University, Egypt
4Family Medicine Department , Faculty of Medicine Zagazig University, Egypt
Abstract
Background and study aim : Many studies have reported that insulin resistance raises the risk of primary hepatocellular carcinoma (HCC). Caspase-generated cytokeratin-18 (CK-18) fragments are produced during apoptosis of hepatic cells. The present study aims to evaluate the value of serum CK-18 and the impact of insulin resistance on recurrence of HCV related HCC in patients treated with radiofrequency ablation (RFA). .
Patients and Methods: The present study was conducted on 60 HCV patients. Group I: 30 patients with HCC treated by RFA and group II: 30 non HCC cirrhotic patients. Insulin resistance was estimated by the homeostatic model assessment of insulin resistance (HOMA-IR) and CK-18 level was measured for all patients using ELISA.
Results: HOMA-IR and CK-18 levels were significantly elevated in HCC patients when compared to non HCC cirrhotic patients. There was a significant increase in CK-18 and HOMA-IR levels in patients with local recurrence versus those with no recurrence (p<0.001). Univariate analysis revealed that HOMA-IR (p=<0.001) and CK-18 (p=<0.001) were significant predictors of recurrence of HCC.
Conclusion: CK-18 and HOMA-IR are potential prognostic markers as they can predict the recurrence of HCC.
Keywords
Hepatocellular carcinoma; homeostatic model assessment of insulin resistance; Caspasegenerated cytokeratine-18; Radiofrequency ablation
Main Subjects
Hepatology
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