Baki, A., Mansour, H., Elkhouly, A., Farrag, O. (2021). The Predictors of Cardio-renal Syndrome among Patients with COVID-19 Infection . Afro-Egyptian Journal of Infectious and Endemic Diseases, 11(1), 51-60. doi: 10.21608/aeji.2020.46958.1109
Aber Halim Baki; Hazem Mansour; Ahmed Tareq Elkhouly; Osama Mohamad Farrag. "The Predictors of Cardio-renal Syndrome among Patients with COVID-19 Infection ". Afro-Egyptian Journal of Infectious and Endemic Diseases, 11, 1, 2021, 51-60. doi: 10.21608/aeji.2020.46958.1109
Baki, A., Mansour, H., Elkhouly, A., Farrag, O. (2021). 'The Predictors of Cardio-renal Syndrome among Patients with COVID-19 Infection ', Afro-Egyptian Journal of Infectious and Endemic Diseases, 11(1), pp. 51-60. doi: 10.21608/aeji.2020.46958.1109
Baki, A., Mansour, H., Elkhouly, A., Farrag, O. The Predictors of Cardio-renal Syndrome among Patients with COVID-19 Infection . Afro-Egyptian Journal of Infectious and Endemic Diseases, 2021; 11(1): 51-60. doi: 10.21608/aeji.2020.46958.1109
The Predictors of Cardio-renal Syndrome among Patients with COVID-19 Infection
1Department of Internal Medicine and Nephrology,Ain Shams University Hospitals,Cairo,Egypt.
2Department of Cardiology,Ain Shams University Hospitals,Cairo,Egypt.
3Department of ICU,Ain Shams University Hospitals,Cairo,Egypt.
Abstract
Background and study aim: : Several reports showed that some Covid-19 patients tend to have serious and fatal complications related to the kidney and heart. Rationale and mechanisms inducing this pathogenesis is unclear, but it’s more common to happen in patients with hemodynamic instability and refractory severe hypotension related to cytokine storm. It represents an irreversible stage of a sepsis-like illness that induces simultaneous damage to various organs as the myocardium and renal tubules alike the cardio-renal syndrome. The predictors for this injurious effect of COVID-19 on both myocardium and renal tissues might be related to the co-morbidities, late presentation and other factors which need further evaluation.The aim of this article is to study the predictors of cardio-renal syndrome in COVID-19 patients Patients and Methods: Our study is a prospective observational study conducted upon confirmed 160 COVID-19 ICU patients admitted from 15th March till 20th May 2020. All patients were subjected to clinical assessment, full laboratory evaluation including PCR for COVID-19 from nasopharyngeal swab and full radiological evaluation.. Results: As regards the predictors for cardio-renal syndrome [15-17]; Age showed high statistically significance (P <0.0004). Furthermore, serum creatinine and serum K were statistically significant in patients with cardio-renal affection (P= 0.015, 0.021) whereas GFR, D-dimer, need for mechanical ventilation and vasopressors were highly statistically significant with cardio-renal affected patients (P <0.001). Conclusion: Cardio-renal syndrome was common in COVID-19 ICU patients. Hypokalemia, lower GFR on admission, mechanical ventilation, vasopressors, age and D-dimer were significant independent predictors for CRS. Moreover,CRS during hospitalization was associated with an increased risk of in-hospital death.
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