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Afro-Egyptian Journal of Infectious and Endemic Diseases
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Volume Volume 11 (2021)
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Baki, A., Mansour, H., Elkhouly, A., Farrag, O. (2021). The Predictors of Cardio-renal Syndrome among Patients with ‎COVID-19 Infection‎ ‎. Afro-Egyptian Journal of Infectious and Endemic Diseases, 11(1), 51-60. doi: 10.21608/aeji.2020.46958.1109
Aber Halim Baki; Hazem Mansour; Ahmed Tareq Elkhouly; Osama Mohamad Farrag. "The Predictors of Cardio-renal Syndrome among Patients with ‎COVID-19 Infection‎ ‎". Afro-Egyptian Journal of Infectious and Endemic Diseases, 11, 1, 2021, 51-60. doi: 10.21608/aeji.2020.46958.1109
Baki, A., Mansour, H., Elkhouly, A., Farrag, O. (2021). 'The Predictors of Cardio-renal Syndrome among Patients with ‎COVID-19 Infection‎ ‎', Afro-Egyptian Journal of Infectious and Endemic Diseases, 11(1), pp. 51-60. doi: 10.21608/aeji.2020.46958.1109
Baki, A., Mansour, H., Elkhouly, A., Farrag, O. The Predictors of Cardio-renal Syndrome among Patients with ‎COVID-19 Infection‎ ‎. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2021; 11(1): 51-60. doi: 10.21608/aeji.2020.46958.1109

The Predictors of Cardio-renal Syndrome among Patients with ‎COVID-19 Infection‎ ‎

Article 8, Volume 11, Issue 1, March 2021, Page 51-60  XML PDF (418.4 K)
Document Type: Original Article
DOI: 10.21608/aeji.2020.46958.1109
Authors
Aber Halim Baki email 1; Hazem Mansour2; Ahmed Tareq Elkhouly3; Osama Mohamad Farrag3
1Department of Internal Medicine and Nephrology,Ain Shams University Hospitals,Cairo,Egypt.
2Department of Cardiology,Ain Shams University Hospitals,Cairo,Egypt.
3Department of ICU,Ain Shams University Hospitals,Cairo,Egypt.
Abstract
Background and study aim: ‎: Several reports showed that some Covid-19 patients tend to have serious and fatal ‎complications related to the kidney and heart. Rationale and mechanisms inducing this ‎pathogenesis is unclear, but it’s more common to happen in patients with hemodynamic ‎instability and refractory severe hypotension related to cytokine storm. It represents an ‎irreversible stage of a sepsis-like illness that induces simultaneous damage to various organs as ‎the myocardium and renal tubules alike the cardio-renal syndrome. The predictors for this ‎injurious effect of COVID-19 on both myocardium and renal tissues might be related to the co-‎morbidities, late presentation and other factors which need further evaluation‎.The aim of this article is to study the predictors of cardio-renal syndrome in COVID-19 patients‎
Patients and Methods: Our study is a prospective observational study conducted upon confirmed 160 COVID-19 ICU ‎patients admitted from 15th March till 20th May 2020. ‎All patients were subjected to clinical assessment, full laboratory evaluation including PCR for ‎COVID-19 from nasopharyngeal swab and full radiological evaluation.‎.
Results: As regards the predictors for cardio-renal syndrome [15-17]; Age showed high statistically ‎significance (P <0.0004). Furthermore, serum creatinine and serum K were statistically ‎significant in patients with cardio-renal affection (P= 0.015, 0.021) whereas GFR, D-dimer, ‎need for mechanical ventilation and vasopressors were highly statistically significant with ‎cardio-renal affected patients (P <0.001)‎‎.
Conclusion: Cardio-renal syndrome was common in COVID-19 ICU patients. Hypokalemia, lower ‎GFR on admission, mechanical ventilation, vasopressors, age and D-dimer were significant ‎independent predictors for CRS. Moreover,CRS during hospitalization was associated with an ‎increased risk of in-hospital death‎‎.
Keywords
Cardiorenal Syndrome (CRS); Covid-19; cytokine storm; Predictors
Main Subjects
Infectious diseases
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