Serum Resistin Level as a Diagnostic Marker in Non-Alcoholic Steatohepatitis

Abdel Monem, Sameh M; Fathy, Talaat; Shalaby, Sally M; Wahab, Essam A

doi:10.21608/aeji.2018.13523

Serum Resistin Level as a Diagnostic Marker in Non-Alcoholic Steatohepatitis

Document Type : Original Article

Authors

¹ Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

² Tropical Medicine Department, Faculty of Mecdicine, Zagazig University, Zagazig, Egypt

³ Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

⁴ Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

10.21608/aeji.2018.13523

Abstract

Background and study aim: Non-alcoholic fatty liver disease (NAFLD) is a state defined by extreme fat accumulation in the form of triglycerides (steatosis) in the liver. A subgroup of NAFLD patients characterized by injury to the hepatocytes and inflammation in addition to excessive fat, the latter condition, nominated non-alcoholic steatohepatitis (NASH). The work aimed to evaluate the role of serum resistin level as a diagnostic marker in patients with non-alcoholic steatohepatitis who were admitted to the Tropical Medicine and Internal Medicine departments, Faculty of Medicine, Zagazig University (inpatient and outpatient).
Patients and Methods: This study was performed on 38 patients between April 2017 to May 2018.They were classified into two groups; control group included 19 non-obese apparently healthy individuals, 11 males and 8 females with average age of 43.2 year and average body mass index of 23.46 Kg/m² and patients group included 19 patients with NASH, 13 males and 6 females with average age of 44 year and average body mass index of 32.71 Kg/m². They had bright fatty liver on ultrasono-graphic examination and raised ALT and AST and liver biopsy confirmed the diagnosis of NASH. Clinical assessment, laboratory evaluation, pelvi-abdominal ultrasound, and serum resistin were done for all participants.
Results: In this study: Cut off level of serum resistin was >3.7 ng/ml and there was a significant difference as regard serum resistin in NASH group in comparison with control group.
Conclusion: Serum resistin level was significantly higher among NASH group in comparison to the control group. Serum resistin level may be a good diagnostic marker for patients with NASH.

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