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Afro-Egyptian Journal of Infectious and Endemic Diseases
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Al-Ghandour, A., Abdelkader, A., Ahmed, H., Darwiesh, E., Moawad, H. (2021). Intestinal Parasitic Infections among Egyptian Patients with Chronic ‎Liver Diseases at Zagazig University Hospital. Afro-Egyptian Journal of Infectious and Endemic Diseases, 11(1), 27-38. doi: 10.21608/aeji.2020.48290.1114
Asmaa Mohammed Farouk Al-Ghandour; Abeer Hussein Abdelkader; Hytham Kamal Ahmed; Ehab M Darwiesh; Howayda Said Moawad. "Intestinal Parasitic Infections among Egyptian Patients with Chronic ‎Liver Diseases at Zagazig University Hospital". Afro-Egyptian Journal of Infectious and Endemic Diseases, 11, 1, 2021, 27-38. doi: 10.21608/aeji.2020.48290.1114
Al-Ghandour, A., Abdelkader, A., Ahmed, H., Darwiesh, E., Moawad, H. (2021). 'Intestinal Parasitic Infections among Egyptian Patients with Chronic ‎Liver Diseases at Zagazig University Hospital', Afro-Egyptian Journal of Infectious and Endemic Diseases, 11(1), pp. 27-38. doi: 10.21608/aeji.2020.48290.1114
Al-Ghandour, A., Abdelkader, A., Ahmed, H., Darwiesh, E., Moawad, H. Intestinal Parasitic Infections among Egyptian Patients with Chronic ‎Liver Diseases at Zagazig University Hospital. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2021; 11(1): 27-38. doi: 10.21608/aeji.2020.48290.1114

Intestinal Parasitic Infections among Egyptian Patients with Chronic ‎Liver Diseases at Zagazig University Hospital

Article 5, Volume 11, Issue 1, March 2021, Page 27-38  XML PDF (563.25 K)
Document Type: Original Article
DOI: 10.21608/aeji.2020.48290.1114
Authors
Asmaa Mohammed Farouk Al-Ghandour email orcid 1; Abeer Hussein Abdelkader2; Hytham Kamal Ahmed3; Ehab M Darwiesh2; Howayda Said Moawad1
1Department of Medical Parasitology,Faculty of Medicine, Zagazig University,Egypt.
2Department Tropical Medicine, Faculty of Medicine, Zagazig University, Egypt‎.
3Department Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt‎.
Abstract
Background and study aim: Regarding the increased number of chronic liver diseases (CLD) patients suffering from ‎many manifestations e.g. diarrhea, this withdrew our attention to try to find a relation ‎between CLD and parasitic infections in those patients‎.
Patients and Methods: A case-control study was performed on 190 participants suffering from gastrointestinal ‎complaints especially diarrhea attending Gastroenterology and Hepatology Outpatient ‎Clinics at Zagazig University Hospital, divided into 2 groups GI: 95 CLD patients. GII: 95 ‎non-CLD Control group patients. Cases underwent clinical, abdominal ultrasonographic, ‎and laboratory liver function assessments. Also, collected patients’ stool samples were ‎microscopically examined using iodine, Trichrome and Modified Ziehl-Neelsen stains. To ‎confirm accurate diagnosis to parasitic infections causing diarrhea, RIDA-ELISA for ‎Cryptosporidium spp. and Giardia lamblia copro-antigens detections was performed.
Results: Parasitic infections among both studied groups were (47%), comprising (58%) in CLD and ‎‎(36%) in non-CLD as follow: Cryptosporidium (28%, 14%), Giardia (15%, 12%), mixed ‎‎(5%, 3%), E.histolytica spp. (5%, 4%), Blastocystis hominis (3%, 1%) and H. nana (1%, ‎‎2%) respectively. The sensitivity, specificity, PPV, NPP and accuracy of ELISA regarding ‎Giardia and Cryptosporidium infections were (100% and 89.6%, 97.5% and 100%, 87.9% ‎and 100%, 100% and 96.6%, 97.9% and 98.4%) respectively. In GI, most giardial cases ‎had normal ALT and AST levels (74%, 63%), but elevated in cryptosporidial infection ‎‎(59%, 66%) respectively, with statistically significant difference‎.
Conclusion: Presence of intestinal parasitic infections; mainly Cryptosporidia and Giardia protozoa ‎among CLD patients was striking when compared to diarrheic non-CLD control group and ‎this may be attributed to impaired immune status.
Keywords
Diarrhea; (CLD); Cryptosporidium spp; Giardia; ELISA
Main Subjects
Endemic medicine; Infectious diseases
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