Abozaid, S., Elshamy, M., Alazim, A., Elhawari, S. (2020). Microwave Ablation and/or Transcatheter Arterial Chemo-embolization in the Treatment of Hepatocellular Carcinoma. Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(4), 407-416. doi: 10.21608/aeji.2020.25284.1054
Sara R Abozaid; Mustafa H Elshamy; Ahmed A Alazim; Soha A Elhawari. "Microwave Ablation and/or Transcatheter Arterial Chemo-embolization in the Treatment of Hepatocellular Carcinoma". Afro-Egyptian Journal of Infectious and Endemic Diseases, 10, 4, 2020, 407-416. doi: 10.21608/aeji.2020.25284.1054
Abozaid, S., Elshamy, M., Alazim, A., Elhawari, S. (2020). 'Microwave Ablation and/or Transcatheter Arterial Chemo-embolization in the Treatment of Hepatocellular Carcinoma', Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(4), pp. 407-416. doi: 10.21608/aeji.2020.25284.1054
Abozaid, S., Elshamy, M., Alazim, A., Elhawari, S. Microwave Ablation and/or Transcatheter Arterial Chemo-embolization in the Treatment of Hepatocellular Carcinoma. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2020; 10(4): 407-416. doi: 10.21608/aeji.2020.25284.1054
Microwave Ablation and/or Transcatheter Arterial Chemo-embolization in the Treatment of Hepatocellular Carcinoma
1Department of Tropical Medicine, Faculty of Medicine, Zagazig University,Egypt.
2Department of Radiology, Faculty of Medicine, Zagazig University,Egypt.
Abstract
Background and study aim: Percutaneous microwave ablation (MWA) and trans-arterial chemo-embolization (TACE) are established therapies for treatment of HCC patients. Lower rates of complete response with mono-therapies have been reported. Therefore, combined treatment strategies, including combined TACE and MWA have been used. The study aimed at comparing the efficacy of MWA mono-therapy; TACE mono-therapy and combined TACE-MWA in the treatment of 3- 5 cm HCC. Patients and methods: The study prospectively included 102 patients with 113 hepatic focal lesions (3-5 cm) diagnosed as HCC by contrast-enhanced triphasic CT or dynamic MRI. Thirty-five HCC in 34 patients were subjected to MWA mono-therapy; 41 HCC in 34 patients were subjected to TACE mono-therapy, while 37 HCC in 34 patients were subjected to combined TACE-MWA therapy. Follow up by contrast-enhanced CT or MRI was done at one month, and every 3 months, up to one year after treatment. Therapeutic tumor response and local tumor progression were evaluated and compared among the groups. Results: After one year follow up, the combined TACE-MWA group showed a higher rate of complete response (CR) (83.3%) when compared to MWA group (76.5%) and TACE group (66.6%) (P>0.05). The local tumor progression (LTP) rate in the combined TACE-MWA group was lower (16.6%) than that in MWA group (23.5%) and TACE group (33.3%) (P=0.2). Conclusion: Combined TACE-MWA therapy appears to be non-significantly superior to MWA mono-therapy and TACE mono-therapy in terms of complete tumor response and local tumor progression in patients with 3-5 cm HCC.
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