• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Afro-Egyptian Journal of Infectious and Endemic Diseases
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 12 (2022)
Volume Volume 11 (2021)
Volume Volume 10 (2020)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 9 (2019)
Volume Volume 8 (2018)
Volume Volume 7 (2017)
Volume Volume 6 (2016)
Volume Volume 5 (2015)
Volume Volume 4 (2014)
Volume Volume 3 (2013)
Volume Volume 2 (2012)
Volume Volume 1 (2011)
Sallam, M., Ahmed, H., Soliman, H., Abdel Monem, S., Abdel Wahab, E. (2020). Prevalence and Predictors of Occult Hepatitis C Infection in High-Risk Egyptian Populations. Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(4), 364-372. doi: 10.21608/aeji.2020.32501.1091
Mohammad M Sallam; Hanan S Ahmed; Hanan H Soliman; Sameh M Abdel Monem; Essam Abdel Wahab. "Prevalence and Predictors of Occult Hepatitis C Infection in High-Risk Egyptian Populations". Afro-Egyptian Journal of Infectious and Endemic Diseases, 10, 4, 2020, 364-372. doi: 10.21608/aeji.2020.32501.1091
Sallam, M., Ahmed, H., Soliman, H., Abdel Monem, S., Abdel Wahab, E. (2020). 'Prevalence and Predictors of Occult Hepatitis C Infection in High-Risk Egyptian Populations', Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(4), pp. 364-372. doi: 10.21608/aeji.2020.32501.1091
Sallam, M., Ahmed, H., Soliman, H., Abdel Monem, S., Abdel Wahab, E. Prevalence and Predictors of Occult Hepatitis C Infection in High-Risk Egyptian Populations. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2020; 10(4): 364-372. doi: 10.21608/aeji.2020.32501.1091

Prevalence and Predictors of Occult Hepatitis C Infection in High-Risk Egyptian Populations

Article 5, Volume 10, Issue 4, December 2020, Page 364-372  XML PDF (370.54 K)
Document Type: Original Article
DOI: 10.21608/aeji.2020.32501.1091
Authors
Mohammad M Sallam1; Hanan S Ahmed2; Hanan H Soliman3; Sameh M Abdel Monem email 4; Essam Abdel Wahab1
1Hepatogastroenterology Unit, Department of Internal Medicine, Faculty of Medicine, Zagazig University, Egypt.
2Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt.
3Department of Public health, Community, Environment and Occupational Medicine, Faculty of Medicine, Suez Canal University, Egypt.
4Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Background and study aim: Direct acting antiviral agents (DAAs) altered hepatitis C virus (HCV) outcomes with a permanent cure in 90% of cases. However, HCV had not wiped out from all cases (1% ~ 15%), which represent occult HCV infection (OCI). The aim of this study is todetect prevalence and predictors of OCI in four high-risk groups.
Patients and Methods: 196 participants were enrolled and assigned into four patients groups and one control group; group I (cryptogenic hepatitis), group II (HCV), group III (chronic HBV), group IV (ESRD), and group V (control group).  HCV RNA testing in serum and in peripheral blood mononuclear cells, hepatic stiffness estimation and FIB-4 score calculation were done for all participants.
Results: Significant differences were found among different study groups regarding frequencies of HTN (p < 0.001) and DM (p < 0.001), history of blood transfusion (p < 0.001), history of previous surgery (p < 0.001), as well as mean values of FIB-4 (p < 0.001) and fibroscan readings (p=0.002). OCI was found in 25 participants (12.7%), with different prevalence rates in different groups; being highest in group I (11/43, 25.3%), followed by group III (6/30, 20%). Among all participants, OCI was significantly associated multiple risk factors that include; history of blood transfusion (p=0.004), previous surgery (p=0.017), positive family history of HCV infection (p < 0.001), advanced fibrosis (p =0.015) and high FIB-4 score (p=0.016). Positive family history of HCV infection and history of blood transfusion were considered as independent predictors for OCI.
Conclusion: Testing for OCI in high-risk populations and retesting in SVR cases might be needed to help in complete eradication of chronic HCV infection.
Keywords
Hepatitis C virus; Direct-acting antiviral agents; Occult HCV infection; PBMCs
Main Subjects
Hepatology; Infectious diseases
Statistics
Article View: 226
PDF Download: 222
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.