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Tawfeek, G., El-Deib, A., Attia, F., El-Nemr, N., Faisal, A., Faisal, A. (2020). Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients. Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(3), 287-293. doi: 10.21608/aeji.2020.22168.1084
Gamal Ahmed Tawfeek; Abd El-Raoof El-Deib; Fadia Mostafa Attia; Nader El-Nemr; Asmaa Salman Faisal; Ahmed Salman Faisal. "Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients". Afro-Egyptian Journal of Infectious and Endemic Diseases, 10, 3, 2020, 287-293. doi: 10.21608/aeji.2020.22168.1084
Tawfeek, G., El-Deib, A., Attia, F., El-Nemr, N., Faisal, A., Faisal, A. (2020). 'Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients', Afro-Egyptian Journal of Infectious and Endemic Diseases, 10(3), pp. 287-293. doi: 10.21608/aeji.2020.22168.1084
Tawfeek, G., El-Deib, A., Attia, F., El-Nemr, N., Faisal, A., Faisal, A. Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2020; 10(3): 287-293. doi: 10.21608/aeji.2020.22168.1084

Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients

Article 8, Volume 10, Issue 3, September 2020, Page 287-293  XML PDF (350.01 K)
Document Type: Original Article
DOI: 10.21608/aeji.2020.22168.1084
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Authors
Gamal Ahmed Tawfeek1; Abd El-Raoof El-Deib1; Fadia Mostafa Attia2; Nader El-Nemr3; Asmaa Salman Faisal4; Ahmed Salman Faisal email 3
1Department of Internal Medicine, Suez Canal University, Ismaillia, 41522, Egypt
2Department of Clinical Pathology, Suez Canal University, Ismaillia, 41522, Egypt.
3Department of Endemic and Infectious Diseases, Suez Canal University, Ismaillia, 41522, Egypt.
4Department of Internal Medicine, Elkantara West Hospital-Ismailia Governorate.
Abstract
Background and study aim: Chronically Hepatitis C virus (HCV)-infected patient, develops many complications, as liver cirrhosis, diabetes, and hepatocellular carcinoma (HCC). This study aimed at evaluation of direct acting anti-viral therapy effect on insulin resistance (IR) and glycemic status in CHC patients with type 2 diabetes mellitus, 3 months after the end of treatment.
Patients and Methods: This prospective work included 72 (better patients) with CHC and type 2 diabetes. All were enrolled for anti-viral therapy at the center for treatment of viral hepatitis in Ismailia Governorate during the period from September 2015 to September 2016. Data from patients’ candidate for anti-viral therapy was collected at pretreatment and after 12 weeks of therapy. The data including, FBS, IR by Homa IR index and quantitative HCV-RNA.
Results: There was a significant decrease in the mean fasting blood sugar (FBS) had occurred after treatment with anti-HCV therapy (p < 0.0001). Also, a significant decrease in the mean of HOMA-IR had occurred after treatment with anti-HCV therapy (p < 0.0001).
Conclusion:  A significant improvement in FBS as well as IR was declared after successful HCV treatment.
Keywords
chronic hepatitis C; direct antiviral drugs; fasting blood sugar; HOMA-IR; cirrhosis
Main Subjects
Infectious diseases
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