Evaluating the Effects of Anti-Viral Therapy on Insulin Resistance and Diabetic Status in Chronic Hepatitis C patients

Document Type : Original Article

Authors

1 Department of Internal Medicine, Suez Canal University, Ismaillia, 41522, Egypt

2 Department of Clinical Pathology, Suez Canal University, Ismaillia, 41522, Egypt.

3 Department of Endemic and Infectious Diseases, Suez Canal University, Ismaillia, 41522, Egypt.

4 Department of Internal Medicine, Elkantara West Hospital-Ismailia Governorate.

Abstract

Background and study aim: Chronically Hepatitis C virus (HCV)-infected patient, develops many complications, as liver cirrhosis, diabetes, and hepatocellular carcinoma (HCC). This study aimed at evaluation of direct acting anti-viral therapy effect on insulin resistance (IR) and glycemic status in CHC patients with type 2 diabetes mellitus, 3 months after the end of treatment.
Patients and Methods: This prospective work included 72 (better patients) with CHC and type 2 diabetes. All were enrolled for anti-viral therapy at the center for treatment of viral hepatitis in Ismailia Governorate during the period from September 2015 to September 2016. Data from patients’ candidate for anti-viral therapy was collected at pretreatment and after 12 weeks of therapy. The data including, FBS, IR by Homa IR index and quantitative HCV-RNA.
Results: There was a significant decrease in the mean fasting blood sugar (FBS) had occurred after treatment with anti-HCV therapy (p < 0.0001). Also, a significant decrease in the mean of HOMA-IR had occurred after treatment with anti-HCV therapy (p < 0.0001).
Conclusion:  A significant improvement in FBS as well as IR was declared after successful HCV treatment.

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Afro-Egyptian Journal of Infectious and Endemic Diseases
Volume 10, Issue 3
September 2020
Pages 287-293

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