• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Afro-Egyptian Journal of Infectious and Endemic Diseases
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 15 (2025)
Volume Volume 14 (2024)
Volume Volume 13 (2023)
Volume Volume 12 (2022)
Volume Volume 11 (2021)
Volume Volume 10 (2020)
Volume Volume 9 (2019)
Volume Volume 8 (2018)
Volume Volume 7 (2017)
Volume Volume 6 (2016)
Volume Volume 5 (2015)
Volume Volume 4 (2014)
Volume Volume 3 (2013)
Volume Volume 2 (2012)
Volume Volume 1 (2011)
Issue Issue 2
Issue Issue 1
Ahmed, M., Ibrahim, G., Bakr, H., Meawed, T. (2011). Assessment Of C-Reactive Protein And Macrophage Migration Inhibitory Factor In Diabetic Foot Infection. Afro-Egyptian Journal of Infectious and Endemic Diseases, 1(2), 19-27. doi: 10.21608/aeji.2011.9054
Mohamed R Ahmed; Gehan A Ibrahim; Hoda G Bakr; Takwa E Meawed. "Assessment Of C-Reactive Protein And Macrophage Migration Inhibitory Factor In Diabetic Foot Infection". Afro-Egyptian Journal of Infectious and Endemic Diseases, 1, 2, 2011, 19-27. doi: 10.21608/aeji.2011.9054
Ahmed, M., Ibrahim, G., Bakr, H., Meawed, T. (2011). 'Assessment Of C-Reactive Protein And Macrophage Migration Inhibitory Factor In Diabetic Foot Infection', Afro-Egyptian Journal of Infectious and Endemic Diseases, 1(2), pp. 19-27. doi: 10.21608/aeji.2011.9054
Ahmed, M., Ibrahim, G., Bakr, H., Meawed, T. Assessment Of C-Reactive Protein And Macrophage Migration Inhibitory Factor In Diabetic Foot Infection. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2011; 1(2): 19-27. doi: 10.21608/aeji.2011.9054

Assessment Of C-Reactive Protein And Macrophage Migration Inhibitory Factor In Diabetic Foot Infection

Article 1, Volume 1, Issue 2, December 2011, Page 19-27  XML PDF (571.63 K)
Document Type: Original Article
DOI: 10.21608/aeji.2011.9054
View on SCiNiTO View on SCiNiTO
Authors
Mohamed R Ahmed1; Gehan A Ibrahim1; Hoda G Bakr email 1; Takwa E Meawed2
1Internal Medicine Department, Faculty of Medicine, Zagazig University,Egypt
2Microbiology and Immunology Department, Faculty of Medicine, Zagazig University,Egypt
Abstract
Background and study aim: : Diabetic foot ulcer is a universal health problem. Neuroischemic changes and infection are responsible for its occurrence and complications. Altered or complete loss of sensation and microvascular disease complicated by unchecked infection can precipitate tissue necrosis and gangrene. A threat for a rapid test predicting early infected foot ulcer emerges. C-reactive protein (CRP) and macrophage migration inhibitory factor (MIF) are involved in innate inflammatory response. We aimed at evaluation of the ability of C-reactive protein and macrophage migration inhibitory factor to differentiate between early infected and non infected diabetic foot ulcers and to detect risk factors of diabetic foot ulceration.
Patients and methods: : 52 diabetic patients were selected, examined and classified into 3 groups : Group (I): Included 12 patients with non-infected diabetic foot ulcer (grade І), group (П): Included 30 patients with mildly infected diabetic foot ulcer (grade П) and group (ПI): Included 11 diabetic patients free from foot wounds used as a control group. In addition to routine laboratory investigations, serum CRP was measured using. Enhanced Immuno-tubidimetric Assay. MIF level was detected by ELISA. Swabs from the diabetic foot ulcers were taken for aerobic and anaerobic cultures.
Results : Statistically significantly elevated Hb A1C%, MIF and CRP levels were detected in mild infected diabetic foot ulcer compared to studied groups (P <0.05). Dermatological changes were statistically significant risk factors for diabetic foot ulcers, accounted for 88.1% of ulcer cases. The most frequently isolated organism was E coli. The most common site for ulcers was the toes representing 50% of the cases.
Conclusion : CRP and MIF can differentiate early infected from non-infected diabetic foot ulcers.
Keywords
C-reactive protein; diabetic foot ulcer; Macrophage Migration Inhibitory Factor
Main Subjects
Endemic medicine; Infectious diseases
Statistics
Article View: 284
PDF Download: 529
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.