• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Afro-Egyptian Journal of Infectious and Endemic Diseases
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 15 (2025)
Volume Volume 14 (2024)
Volume Volume 13 (2023)
Volume Volume 12 (2022)
Volume Volume 11 (2021)
Volume Volume 10 (2020)
Volume Volume 9 (2019)
Volume Volume 8 (2018)
Volume Volume 7 (2017)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 6 (2016)
Volume Volume 5 (2015)
Volume Volume 4 (2014)
Volume Volume 3 (2013)
Volume Volume 2 (2012)
Volume Volume 1 (2011)
Mostafa, A., Ramadan, N., Zaghloul, M., Farag, M. (2017). Role of Serotonin in Development of Varices in Patients with Cirrhosis. Afro-Egyptian Journal of Infectious and Endemic Diseases, 7(4), 177-185. doi: 10.21608/aeji.2017.17800
Adel Awad Mostafa; Naglaa El-Toukhy Ramadan; Mohamed Hossam El-Din Zaghloul; Mohamed E. Farag. "Role of Serotonin in Development of Varices in Patients with Cirrhosis". Afro-Egyptian Journal of Infectious and Endemic Diseases, 7, 4, 2017, 177-185. doi: 10.21608/aeji.2017.17800
Mostafa, A., Ramadan, N., Zaghloul, M., Farag, M. (2017). 'Role of Serotonin in Development of Varices in Patients with Cirrhosis', Afro-Egyptian Journal of Infectious and Endemic Diseases, 7(4), pp. 177-185. doi: 10.21608/aeji.2017.17800
Mostafa, A., Ramadan, N., Zaghloul, M., Farag, M. Role of Serotonin in Development of Varices in Patients with Cirrhosis. Afro-Egyptian Journal of Infectious and Endemic Diseases, 2017; 7(4): 177-185. doi: 10.21608/aeji.2017.17800

Role of Serotonin in Development of Varices in Patients with Cirrhosis

Article 2, Volume 7, Issue 4, December 2017, Page 177-185  XML PDF (473.91 K)
Document Type: Original Article
DOI: 10.21608/aeji.2017.17800
View on SCiNiTO View on SCiNiTO
Authors
Adel Awad Mostafa1; Naglaa El-Toukhy Ramadan1; Mohamed Hossam El-Din Zaghloul2; Mohamed E. Farag3
1Hepatology, Gastroenterology and Infectious Diseases Department, Faculty of Medicine, Benha University-Benha-Egypt
2Clinical Pathology Department, Faculty of Medicine – Mansoura University- Mansoura -Egypt
3Hepatology, Gastroenterology and Infectious Diseases Department, Shebein El-Kom Teaching Hospital- Shebein El-Kom-Egypt
Abstract
Background and study aim: Serotonin is a one of the monoamine neurotransmitters secreted by serotonergic nerve endings in multiple sites in the brain and gastro-intestinal tract wall. The presence of serotonin receptors on hepatic stellate cells can cause contraction of these cells closing the sinusoidal fenestrae and raising the portal vein pressure. The aim of this work is to study the relation between free serotonin level and the presence of varices in patients with cirrhosis.
Patients and Methods: This prospective case control study was carried out on 70 patients with liver cirrhosis attended or admitted to Hepatology Department in Shebein El-Kom Teaching Hospital within the period between May and October 2015. They divided into two groups: Group 1:  40 patients with varices diagnosed by upper GIT endoscopy. Group 2:  30 patients without varices. In addition, 20 healthy persons served as control group (Group 3). All subjects were subjected to full history taking, clinical examination and laboratory investigation including plasma free serotonin by Enzyme Linked Immunosorbant Assay (ELISA).
Results: serum serotonin level in group I was significantly higher than group II and control group. Serum serotonin level was significantly correlated to esophageal varices grade, Child, MELD and updated MELD scores. It was also clear that serotonin level rises significantly with higher grades of esophageal varices.
Conclusion: Free serotonin had a good power of prediction for development of varices and correlated well with severity of liver disease in patients with cirrhosis assessed by Child, MELD and updated MELD scores as well as OV grade.
Keywords
Serotonin- Varices in Patients with Cirrhosis- MELD score
Main Subjects
Hepatology
Statistics
Article View: 391
PDF Download: 613
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.