Vitamin D Profile : Can it Affect the Response to Standard Hepatitis C Treatment in Egyptian Patients ?

Document Type : Original Article

Authors

1 Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

2 Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Abstract

Background and study aim : Vitamin D is a potent immunomodulator. It is reported to be related to the severity of fibrosis and responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C (CHC), so we aimed to evaluate if there is an association between vitamin D metabolism related genes and vitamin D level with the degree of liver damage and the response to treatment of CHC in our locality.
Patients and methods : Two hundred and forty five Egyptian patients (123 patients with sustained virological response and 122 patients with treatment failure) were included. They were subjected to routine investigation needed for treatment, in addition to estimation of 25-OH vitamin D level in serum by ELISA and CYP27B1-1260 gene polymorphism by PCR-RFLP method. 
Results: We found that serum levels of vitamin D showed statistically significant increase in responders in comparison with non responders. The distribution of CYP27B1-1260 AC and CC genotypes were significantly presented in the non responders in comparison with the responders. CYP27B1-1260 AC and CC genotypes carriers had a high risk for treatment failure, (OR= 14.7, 95% CI= 2.3-20.1, P<0.001; OR = 20.4, 95% CI= 2.9-21.3, P Conclusion: Vitamin D serum level and CYB27B1 -1260 genotype could be used as a predictor to anti HCV treatment response in our locality.

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