Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Call for Emergency Action to Limit Global Temperature Increases, Restore Biodiversity, and Protect Health
216
219
EN
Lukoye
Atwoli
Editor in chief, East African Medical Journal
Abdullah
H
Baqui
Editor in chief, Journal of Health, Population and Nutrition
Thomas
Benfield
Editor in chief, Danish Medical Journal
Raffaella
Bosurgi
Editor in chief, PLOS Medicine
Fiona
Godlee
Editor in chief, The BMJ
Stephen
Hancocks
Editor in chief, British Dental Journal
Richard
Horton
Editor in chief, The Lancet
Laurie
Laybourn-Langton
Senior adviser, UK Health Alliance on Climate Change
laurie.laybourn@ukhealthalliance.org
Carlos
Augusto Monteiro
Editor in chief, Revista de Saúde Pública
Ian
Norman
Editor in chief, International Journal of Nursing Studies
Kirsten
Patrick
Interim editor in chief, CMAJ
Nigel
Praities
Executive editor, Pharmaceutical Journal
Marcel
GM
Olde Rikkert
Editor in chief, Dutch Journal of Medicine
Eric
J. Rubin
Editor in chief, NEJM
Peush
Sahni
Editor in chief, National Medical Journal of India
Richard
Smith
Chair, UK Health Alliance on Climate Change
Nicholas
J
Talley
Editor in chief, Medical Journal of Australia
Sue
Turale
Editor in chief, International Nursing Review
Damián
Vázquez
Editor in chief, Pan American Journal of Public Health
10.21608/aeji.2021.193111
<span>The risks to health of increases above 1.5°C are now well established . Indeed, no <span lang="AR-SA"></span>temperature rise is “safe.” In the past 20 years, heat related mortality among people aged over <span lang="AR-SA"></span>65 has increased by more than 50%. Higher temperatures have brought increased dehydration <span lang="AR-SA"></span>and renal function loss, dermatological malignancies, tropical infections, adverse mental health <span lang="AR-SA"></span>outcomes, pregnancy complications, allergies, and cardiovascular and pulmonary morbidity and <span lang="AR-SA"></span>mortality. Harms disproportionately affect the most vulnerable, including among children, <span lang="AR-SA"></span>older populations, ethnic minorities, poorer communities, and those with underlying health <span lang="AR-SA"></span>problems .</span>
Climate Change,public health
https://aeji.journals.ekb.eg/article_193111.html
https://aeji.journals.ekb.eg/article_193111_b57d3cf5915b32c3a82c0a880c10ce3d.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Helicobacter pylori: Not just a Gastric Infection
220
222
EN
Mohamed
H
Emara
0000-0002-1504-7851
Hepatology, Gastroenterology and Infectious Diseases. Faculty of Medicine,
Kafrelsheih University, Egypt
emara_2007@yahoo.com
10.21608/aeji.2021.191188
Salama et al., in the current issue of Afro-Egypt J Infect Endem Dis published an interesting article focusing the prevalence of <em>H pylori</em> among patients with persistent itching. The authors reported a prevalence of <em>H pylori</em> among 130 out of 280 patients (46.4%) of persistent itching after exclusion of the common causes of itching. The authors reported 60% complete response defined as disappearance of itching after 2-weeks of <em>H pylori</em> treatment. Furthermore, 20% of patients reported partial improvement while 20% did not improve in comparison to 0% among the <em>H pylori</em> negative group treated with anti-histaminics. The authors reported also Ig E levels to be significantly higher among <em>H pylori</em> negative cases ruling out the allergic mechanism as a cause of skin affection in <em>H pylori</em> infected subjects.
Helicobacter pylori,Itching, Gastric
https://aeji.journals.ekb.eg/article_191188.html
https://aeji.journals.ekb.eg/article_191188_236f06e3c1367178ed01c081a8194e49.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Infection Control Measures of COVID-19 at Endoscopy Units: Knowledge and Practice of Gastrointestinal Endoscopists
223
232
EN
Haidi
Karam-Allah
Ramadan
0000- 0003-0627-3985
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut
University, Assiut, Egypt.
haidikaram@aun.edu.eg
Hanan
Sharaf El Deen
Mohammed
Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut,
Egypt.
dr_hanansharaf@yahoo.com
Adnan
Ahmed
Mohamed
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut
University, Assiut, Egypt.
adnan10017.aa@gmail.com
Ahmed
Shawkat
Abdelmohsen
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut
University, Assiut, Egypt.
shawkatahmed84@aun.edu.eg
10.21608/aeji.2021.73717.1146
<strong>Background and study aims:</strong>The health care workers at endoscopy units are at a high risk of COVID-19 infection. Several guidelines for COVID-19 infection control measures at endoscopy units are available. However, the knowledge and practice of endoscopists toward these measures are not evaluated. We aimed to assess the level of knowledge and practice of Egyptian gastrointestinal (GI) endoscopists for these measures.<br /> <strong>Patients and Method:</strong>An online questionnaire was filled by the GI endoscopists. It consisted of 4 sections; the demographic features of the participants, pre-endoscopic infection control measures, during endoscopy on COVID-19 patients measures and post-endoscopic measures. Each of the last 3 sections contained questions assessing the knowledge and practices of the endoscopists. The answers to some questions were set up as ‘yes’ or ‘no’ and the other questions required selecting the appropriate answer.<br /> <strong>Results: </strong>A total of 120 participants completed the questionnaire. About half had endoscopic experience between 5 and 10 years. The overall correct answers regarding the knowledge were 45.6% while 62.2% for the practice. Low percent of correct answers was related to the personal protective equipment (PPE) use. About 56.7% and 58.3% found their level of knowledge and practices to be fair, respectively.<br /> <strong>Conclusion: </strong>The knowledge of the infection control against COVID-19 was insufficient among GI endoscopists particularly PPE use. Meanwhile, the practice was relatively adequate due to hospital policies of strict application of infection control measures.
COVID-19,Infection control,Knowledge,Endoscopists,personal protective equipment
https://aeji.journals.ekb.eg/article_176467.html
https://aeji.journals.ekb.eg/article_176467_dcfe6144b677e18df2a714c3fd13d155.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients
233
240
EN
Magda
Shehata
Hassan
Department of Tropical Medicine and Gastroenterology, Assiut University Hospital,
Faculty of Medicine, Assiut University, Egypt.
magda_sh@yahoo.com
Nariman
Zaghloul
Bekhiet
Department of Tropical Medicine and Gastroenterology, Assiut University Hospital,
Faculty of Medicine, Assiut University, Egypt.
narimandoctor@med.aun.edu.eg
Mohammed
Fawzy
Adam
Department of Chest Diseases and Tuberculosis, Assiut University Hospital,
Faculty of Medicine, Assiut University, Egypt
mohamedadam200010@yahoo.com
Adnan
Ahmed
Mohamed
Department of Tropical Medicine and Gastroenterology, Assiut University Hospital,
Faculty of Medicine, Assiut University, Egypt.
adnan10017.aa@gmail.com
10.21608/aeji.2021.62307.1137
<strong>Background and aim:</strong> For a long time, the connection between liver cirrhosis (LC) and infections had been studied extensively. Because of their weakened immune system, cirrhotic patients are more likely to contract infectious diseases. Cirrhotic patients are more likely to undergo invasive diagnostic or surgical procedures that can change the host's protective barrier, putting them at a higher risk of contracting an infection.<br /> <strong>Patients and Methods:</strong> The study was conducted over one year duration between January and December 2019 at intensive care unit (ICU). It enrolled all patients with decompensated LC but patients with compensated LC or underlying chronic chest disease were excluded. Baseline evaluation with laboratory data was done in all patients. Blood and sputum cultures were achieved in patients with suspected NCI.<br /> <strong>Results: </strong>845 patients with LC were admitted to ICU but 345 of them were excluded so, 500 patients were enrolled in the analysis. NCI occurred in 100 (20%) patients. The most frequent isolated organisms were Klebsiella species (32%), Candida albicans (19%), Strept.pneumoniae (12%) and Staph.aureus (10%). All of these infections were in form of pneumoniae. Up to 65% of patients with NCI were died. Based on the current study the predictors of NCI were; old age spontaneous bacterial peritonitis and low serum albumin.<br /> <strong>Conclusion: </strong>Patients with liver cirrhosis are liable to infections secondary to dysregulated immunity. NCI in cirrhotic patients has serious outcome. Hospitalized cirrhotic patients should be screened for NCI.
Keywords: nosocomial chest infection,Liver cirrhosis,Spontaneous Bacterial Peritonitis
https://aeji.journals.ekb.eg/article_176803.html
https://aeji.journals.ekb.eg/article_176803_a6f38bb603b0b75b4e0dae3281361333.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
The Value of Combined Measuring of the Cerebrospinal Fluid Lactate and Serum Procalcitonin in Diagnosis of Acute Bacterial Meningitis
241
248
EN
Hosam
M
Dawod
https://orcid.org/00
Department of Tropical Medicine Department, Faculty of Medicine, Zagazig
University, Egypt.
hosamgastro@yahoo.com
Ahmed
S
Awadallah
Medicine Department, Zagazig Fever Hospital, Egypt.
ahmedsamirawadallah@gmail.com
Seham
Mahrous
Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt.
sehammahrous@gmail.com
Ahmed
Alwassief
Department of Internal Medicine, Al Azhar University for Boys, Cairo Campus, Egypt
ahmedalwassief@gmal.com
Sameh
M
Abdel Monem
Department of Tropical Medicine Department, Faculty of Medicine, Zagazig
University, Egypt.
drsameh154@yahoo.com
10.21608/aeji.2021.71520.1143
<strong>Backgroundand study aim:</strong>The differential diagnosis between bacterial meningitis and aseptic meningitis is a critical clinical issue and searching for reliable and valid markers is required. This work aimed to assess the role of the combined measuring of CSF lactate and serum procalcitonin in the diagnosis of acute bacterial meningitis.<br /> <strong>Patients and Method:</strong>A cross-sectional study including 42 meningitis patients was conducted at Zagazig Fever Hospital and Zagazig University Hospitals in the period from November 2018 to June 2019, Patients were divided according to their final diagnosis into two groups; group I included 13 patients with bacterial meningitis ( positive CSF bacterial culture and/or Gram stain ), group II included 29 patients with aseptic meningitis (negative CSF bacterial culture and Gram stain), The data collection sheet included clinical assessments, lumbar puncture with CSF analysis, CSF lactate level testing, and Serum procalcitonin level testing.<br /> <strong>Results: </strong>One hundred five of house officer participated Serum procalcitonin and CSF lactate levels were significantly higher in the bacterial meningitis group (1.16 ±1.24, 7.5 ± 6.6, respectively) than patients with aseptic meningitis (0.059 ± 0.04, 3.98 ± 2.1, respectively). The measuring of both serum procalcitonin and CSF lactate levels had got a higher sensitivity, specificity, and accuracy (96.6%, 76.9%, 90.9% respectively) for the diagnosis of bacterial meningitis more than measuring either of them only.<br /> <strong>Conclusion: </strong>The combined measuring of both serum procalcitonin and CSF lactate levels is highly accurate in the diagnosis of bacterial meningitis cases and helps to differentiate bacterial meningitis from aseptic meningitis.
Bacterial Meningitis,Procalcitonin,Lactate,CSF
https://aeji.journals.ekb.eg/article_177730.html
https://aeji.journals.ekb.eg/article_177730_6d088a3fb45f20659dbf966344aa4d69.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Knowledge, Attitude and Practice Associated with COVID-19 among Egyptian House Officers: Online Cross-Sectional Survey
249
256
EN
Mohammed
Hussien Ahmed
0000-0003-1761-3527
Department of Hepatology, Gastroenterology and Infectious Disease, Faculty of
Medicine, Kafrelsheikh University.
dr.mm63@yahoo.com
Mohamed
Neguib
Department of Psychiatry, Faculty of Art, Kafrelsheikh University.
mns205010@gmail.com
Hebat Allah
Abdel maksoud Ahmed
Department of Community Medicine, Faculty of Medicine, Kafrelsheikh University,
Kafrelsheikh, Egypt.
heba_abdelmasoud@med.kfs.edu
Hassan
El-shirbiny
Department of Hepatology, Gastroenterology and Infectious Disease, Faculty of
Medicine, Kafrelsheikh University.
hassanelshirbiny2010@gmail.com
Aya
Mohamed
Mahros
Department of Hepatology, Gastroenterology and Infectious Disease, Faculty of
Medicine, Kafrelsheikh University.
yoye_85@hotmail.com
10.21608/aeji.2021.62907.1138
<strong>Background and study aim:</strong> House officers' adherence to fight COVID -19, especially after declaration of WHO that coronavirus as a pandemic, is essential. This is markedly influenced by their knowledge, attitude, and practices (KAPs). We aimed to assess the knowledge, attitude and the practice toward (COVID-19) among Egyptian house officers .<br /> <strong>Method:</strong> A questionnaire-based- online survey by Google Forms was carried out over three months, between March 2020 and May 2020. Answers to all questionnaire items were obligatory, and submission was not allowed till all questions were answered. Each questionnaire consists of two main parts. Personal information (name, age). Additionally, we assess knowledge, attitude, and practice towards COVID-19 pandemic (prevention, diagnosis, lines of treatment, and others) .<br /> <strong>Results: </strong>One hundred five of house officers participated in this study (64.7% of them were females and 35.3% were males). Regarding the Knowledge of the house officers about COVID-19 infection 61.7% of the participants mentioned that the use of PPE and physical isolation for two weeks must be observed by health care workers who had contact with COVID-19 patients. The total score for House officer's knowledge was 6/7. About 71% of house officers mentioned that they are happy to be a physician despite this; 31.4% only accepted that the physician takes considerable respect from the community and the government. 63.7% said that they could share the responsibility to fight the COVID-19 pandemic with the health care providers. The total score for attitude was 4\7. Precautions during the training courses at the hospital were observed in 81.4% of house officers. The total score of house officer's practice was 2/4.<br /> <strong>Conclusion: </strong>Most of the house officers had good knowledge and a positive attitude toward COVID-19. However, this was less than we hope for their essential role in this pandemic. We recommend continuous educational courses for COVID-19 diagnoses and management for house officers to be one of the first lines for COVID-19 fighting.
Key words: COVID-19 pandemic,House officer adherence to control measures,Knowledge,Attitude and Practice
https://aeji.journals.ekb.eg/article_178413.html
https://aeji.journals.ekb.eg/article_178413_4c4d7cfbc257fa9d6578f003fba9c295.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Diagnostic Performance of Line Probe Assay for the Diagnosis of Rifampicin and Isoniazid Resistant Tuberculosis in a Resource-Poor Country
257
264
EN
Laura
Madukaji
APIN, Public Health Initiative, Abuja, Nigeria .
lauradonbebe@yahoo.com
Francis
Ejeh
0000-0002-2586-3588
Department of Veterinary Microbiology, University of Maiduguri, Nigeria.
enenchefrancis@yahoo.com
Eke
Ofuche
APIN, Public Health Initiative, Abuja, Nigeria .
eofuche@apin.org.ng
Jay
Samuel
APIN, Public Health Initiative, Abuja, Nigeria .
jsamuels@apin.org.ng
Femi
Owolagba
APIN, Public Health Initiative, Abuja, Nigeria .
fowolagba@apin.org.ng
Ughweroghene
Omo-Emmanuel
USAID, Abuja, Nigeria.
uomoemmanuel@usaid.gov
Prosper
Okonkwo
APIN, Public Health Initiative, Abuja, Nigeria .
pokonkwo@apin.org.ng
10.21608/aeji.2021.71788.1147
<strong>Background and study aim:</strong> The use of LPA is still new in Nigeria and only available in TB reference laboratories. In this study, the performance of LPA version 2.0 was evaluated for the detection of resistant to first-line anti-TB drugs.<br /> <strong>Patients and Methods:</strong> We evaluated the performance of LPA version 2.0 for the detection of rifampicin (RIF) and isoniazid (INH) resistance. Sputum samples from 223 participants were subjected to phenotypic drug susceptibility testing (PDST) and LPA. Statistical analyses included calculation of sensitivity, specificity, positive and negative predictive values. Cross tabulation was done along the kappa test to measure the degree of agreement between PDST and LPA. P-Value > 0.05 was considered significant.<br /> <strong>Results: </strong>The overall sensitivity and specificity of 89.6% (95% C.I 82.5-94.5%) and 65.4% (95% C.I 44.3-82.7%) for detection of RIF resistance; for INH they were 76.6 (95% C.I 67.5-84.5%) and 76.7% (95% C.I 49.5-82.6%); and for MDR-TB, they were 67.0% (95% C.I 56.4-76.5%) and 72.0% (95% C.I 57.6-83.7%). The kappa values were 0.53 (0.001), 0.38 (p = 0.000) and 0.36 (p = 0.000) for the detection of RIF, INH and MDR-TB. There was moderate agreement between PDST and LPA for detection of RIF (κ = 0.57; P = 0.0001), INH (κ = 0.44; P = 0.0001), MDR-TB (κ = 0.43; P = 0.001).<br /> <strong>Conclusion: </strong>The Line probe assay has good sensitivity and specificity for detecting rifampicin and isoniazid. However, the overall performance is moderate; this should be considered when interpreting the assay’s results.
Infectious diseases,tuberculosis diagnoses,line probe assay,HIV/AIDS,Multi-drug-resistant tuberculosis
https://aeji.journals.ekb.eg/article_179587.html
https://aeji.journals.ekb.eg/article_179587_5d9a73aa5b48d34b6106e62d09634a88.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Helicobacter Pylori infection and Persistent Itching
265
269
EN
Rasha
Salama
0000-0001-6285-8465
Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig,
Egypt .
rashasalama1010@gmail.com
Amira
Amin Salem
Tawoos
Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
amiratawoos@yahoo.com
Ehab
Darwiesh
Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig,
Egypt .
ehab_drwish_123@yahoo.com
10.21608/aeji.2021.80619.1152
<strong>Background and study aim:</strong> <em>Helicobacter (H) pylori</em> is a worldwide prevalent infection with wide range of gastric and extra-gastric diseases. There is evidence in the literature linking <em>H pylori</em> to many skin diseases. The current study aimed at determining the frequency of <em>H pylori</em> among patients with persistent itching and evaluates impact of <em>H pylori</em> treatment on the course of the disease.<br /> <strong>Patients and Methods:</strong> Two hundred eighty patients with persistent itching were tested for <em>H pylori</em> antigen in their stool. Patients with and without <em>H pylori</em> antigen positivity were compared. <em>H pylori</em> positive cases were treated by 2 weeks regimens.<br /> <strong>Results: </strong>One hundred thirty patients (46.4%) were positive for <em>H pylori</em> stool antigen. Patients with and without <em>H pylori</em> stool antigen positivity were comparable in their demographic and laboratory parameters except for Ig E which was more positive among <em>H pylori</em> negative cases. <em>H pylori</em> positive cases had 60%, 20%, and 20% rates of complete resolution, partial resolution and non-resolution of itching after <em>H pylori</em> treatment respectively.<br /> <strong>Conclusion: </strong>Among patients with persistent itching recruited in the current study, 46.4% had an evidence of <em>H pylori</em> infection. <em>H pylori</em> positive cases with persistent itching did not have elevated Ig E levels. Out of 130 <em>H pylori</em> positive cases 60% had complete resolution of itching after treatment of <em>H pylori</em>.
Helicobacter pylori,Itching, Ig E
https://aeji.journals.ekb.eg/article_182154.html
https://aeji.journals.ekb.eg/article_182154_4a3cc9ff4a8a09b2ee07bb994d883cf4.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Role of Serum Ascites Albumin Gradient (SAAG) and Portal Vein Congestion Index as Non-Invasive Methods for Prediction of Esophageal Varices in Cirrhotic Patients
270
283
EN
Gamal
S
Eldeeb
Department of Tropical Medicine, Faculty of Medicine, Menoufia University,
Menoufia, Egypt.
gamaleldeeb_2015@hotmail.com
Shimaa
A
Hassanein
Department of Diagnostic Radiology, Faculty of Medicine - Menoufia University,
Menoufia, Egypt.
shaimaahmid@hotmail.com
Ibrahim
E
Abd-Elmawla
M.B. B. Ch.
i.desouky1980@gmail.com
Naglaa
Said
Elabd
0000-0001-8786-0190
Department of Tropical Medicine, Faculty of Medicine, Menoufia University,
Menoufia, Egypt.
naglaa_elabd@yahoo.com
10.21608/aeji.2021.81275.1151
<strong>Background and aim:</strong> Majority of cirrhotic patients develop varices, the rate of variceal bleeding is 10-30% yearly with death rate from bleeding is 17-57%. esophagogastroduodenoscopy (EGD) is an invasive and unpleasant technique carrying rare but serious complications. We aimed to investigate the serum ascites albumin gradient (SAAG) and portal vein congestion index (PCI) as non-invasive methods for prediction of esophageal varices (EV) in patients with liver cirrhosis.<br /> <strong>Patients and Methods:</strong> 125 cirrhotic patients with ascites and no past history of EGD were included. Patients were grouped into; Group I: 38 cirrhotic patients without EV. Group II: 87 cirrhotic patients with EV. Patients were subjected to full clinical evaluation, calculation of SAAG, abdominal ultrasound with a duplex study and measurement of PCI, and Esophagogastroduodenoscopy for detection and grading of esophageal varices .<br /> <strong>Results: </strong>Cirrhotic patients with EV had higher SAAG values (1.85 ± 0.24 gm/dl) than cirrhotic patients without EV (1.27 ± 0.15 gm/dl). Additionally, cirrhotic patients with EV showed a higher PCI than those without (0.16 ± 0.02 and 0.12 ± 0.01 respectively). For prediction of EV in cirrhotic patients, SAAG had AUC 0.986 (p < 0.001) with cutoff >1.4 with sensitivity 97.70% and specificity 89.47% and portal congestion index, AUC was 0.974 (p < 0.001) with cutoff >0.135 had sensitivity 90.80% and specificity 94.74%.<br /> <strong>Conclusion: </strong>SAAG could be used as a non-invasive predictor for the presence of EV in cirrhotic patients along with SAAG cutoff >1.4 requiring clinical attention. Combination of SAAG and PCI had a high ability to predict esophageal varices in cirrhotic patients with AUC 1.000.
Cirrhosis,Esophageal varices,SAAG,portal congestion index
https://aeji.journals.ekb.eg/article_191001.html
https://aeji.journals.ekb.eg/article_191001_ec61ed69b8f83c13d1303f22544a9bac.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Clinical and Laboratory Predictors for ICU Admission among COVID-19 Infected Egyptian Patients, A multi-Center Study
284
294
EN
Shimaa
Elsharawy
Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Egypt
shaimaa.elsharawy@med.tanta.edu.eg
Ibrahim
Amer
Department of Hepatology, Gastroenterology and Infectious Diseases, Faculty of Medicine, Kafr El Sheikh University, Egypt.
ebrahiem.amier30@med.kfs.edu.eg
Marwa
Salama
Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Egypt
marwa.salama@med.tanta.edu.eg
Walaa
El-Lawaty
Department of Chest Diseases, Faculty of Medicine, Tanta University, Egypt.
drwallaellawatty@gmail.com
Mohamed
Abd Elghafar
Department of Anesthesia, Surgical Intensive Care and Pain Management, Tanta University, Egypt
mohamed.abdelghafar1@med.tanta.edu.eg
Amany
Ghazi
Department of Microbiology and Medical Immunology, Faculty of Medicine, Kafr El Sheikh University, Egypt
ghazy.amany@yahoo.com
Nehad
Hawash
Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Egypt
nehad.hawash@med.tanta.edu.eg
10.21608/aeji.2021.82473.1155
<strong>Background and study aim:</strong> The incremental global spread of the SARS-CoV-2 virus imposes an enormous burden on medical health systems. We focused on determining the predictors for the COVID-19 patient's course of illness and what level of care will be actually needed at hospital admission.<br /> <strong>Patients and Methods:</strong> 170 symptomatic COVID-19 Egyptian patients were gleaned from August 2020 to January 2021, were categorized into a group that managed at home or ward admitted and a group that necessitated ICU hospitalization at Tanta University or Kafr El-sheikh University isolation hospitals. Each patient's demographics, clinical, laboratory, and radiological data were gathered and several classification strategies were applied. The variables that predicted the severity of disease and ICU admission were established via logistic regression. The area under the receiver operating characteristic curve was used to assess performance.<br /> <strong>Results: </strong>The top risk variables predicting ICU admission were blood oxygen saturation (P<0.001), serum ferritin (P= 0.023), WHO assessment scale (P= 0.001) and presence of fatigue (P= 0.001) or myalgia (P= 0.028) and with the best accuracy for WHO assessment scale >4 and oxygen saturation ≤90 with an AUC of 0.850 (95% CI [0.795 – 0.905]) and 0.800 (95% CI [0.735 – 0.865]), respectively.<br /> <strong>Conclusion: </strong>Fatigue, myalgia, oxygen saturation, pulse, respiratory rates, ferritin, and C- reactive protein may prove useful for physicians to distinguish which COVID-19 patients will be required to be managed critically at hospital admission.
COVID-19,predictors,ICU
https://aeji.journals.ekb.eg/article_191002.html
https://aeji.journals.ekb.eg/article_191002_63789618e5359b0e8dd5863090290cde.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Baseline Characteristics and Outcomes of 180 Egyptian COVID-19 Patients Admitted to Quarantine Hospitals of Ain Shams University: A Retrospective Comparative Study
295
305
EN
Sara I.
Taha
0000-0001-8224-8701
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University
Cairo, Egypt.
dr_sara_ib@med.asu.edu.eg
Sara
F
Samaan
Department of Internal Medicine/ Rheumatology, Faculty of Medicine, Ain Shams
University, Cairo, Egypt .
dr.sara_farid@yahoo.com
Aalaa
K
Shata
Department of Pulmonary Medicine, Faculty of Medicine, Ain Shams University,
Cairo, Egypt .
aalaashata@yahoo.com
Shereen
A
Baioumy
0000-0002-2188-6790
Department of Microbiology and Immunology, Faculty of Medicine, Zagazig
University, Zagazig, Egypt .
drshereenatef@yahoo.com
Shaimaa
A
Abdalgeleel
0000-00003-0994-7703
Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo
University, Cairo, Egypt .
shaimaa.abdalgeleel@nci.cu.edu.eg
Mariam
K
Youssef
0000-0003-2075-3889
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University
Cairo, Egypt.
dr.mariam_karam@hotmail.com
10.21608/aeji.2021.84683.1157
<strong>Background and study aim:</strong> COVID-19 mortality, severity, and recovery are major global concerns, but they are still insufficiently understood, particularly in the Middle East. This retrospective study aimed to investigate the link between baseline clinical and laboratory data of COVID-19 patients and disease severity and mortality.<br /> <strong>Patients and Methods:</strong> A total of 180 adult Egyptian COVID-19 patients were compared according to their disease severity and mortality .<br /> <strong>Results: </strong>The Of all, 27.8% had severe disease, and 13.9% died during their hospital stay. Diabetes (46.7%), hypertension (36.1%), and chronic obstructive pulmonary disease (COPD) (33.3%) were the most frequent associated co-morbidities. Severe patients and non-survivors were significantly older compared to their corresponding groups. Their neutrophil count, PCT, ESR, CRP, AST, ALT, LDH, D-dimer, and ferritin levels were significantly higher (P ≤ 0.05). In contrast, their lymphocyte count was significantly lower (P ≤ 0.05). COPD (OR: 3.294; 95% CI: 1.199-9.053), diabetes (OR: 2.951; 95% CI:1.070-8.137), ferritin ≥ 350 ng/mL (OR: 11.08; 95% CI: 2.796-41.551), AST ≥ 40 IU/L (OR: 3.07; 95% CI: 1.842-7.991), CT-scoring system (CT-SS) ≥ 17 (OR: 1.205; 95% CI: 1.089-1.334) and lymphocyte count < 1×103/µL (OR: 4.002; 95% CI: 1.537-10.421), were all linked to higher COVID-19 severity. While mortality was predicted by dyspnea (OR: 4.006; 95% CI: 1.045-15.359), CT-SS ≥ 17 (OR: 1.271; 95% CI: 1.091-1.482) and AST ≥ 40 IU/L (OR: 2.89; 95% CI: 1.091-7.661).<br /> <strong>Conclusion: </strong>Clinical and laboratory data of COVID-19 patients at their hospital admission may aid in identifying early risk factors for severe illness and mortality rates .
COVID-19,Egypt,Indicators,mortality,severity
https://aeji.journals.ekb.eg/article_191003.html
https://aeji.journals.ekb.eg/article_191003_f779d6b65b04dc1cbd44c5620c45f259.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Measles IgG Antibodies: Is There a Protective Role in COVID 19 Pandemic?
306
313
EN
Amira
Al Balakosy
0000-0002-9229-6237
Department of Tropical Medicine, Faculty of Medicine, Ain Shams University Abbasia
square, Cairo, Egypt.
drbalakosy@gmail.com
Mostafa
Alfishawy
Infectious Diseases Consultants and Academic Researchers of Egypt committee, Cairo, Egypt.
malfishaway@kasralainy.edu.eg
Omnia
Elnabawy
0000-0001-7060-6196
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University,
Abbasia square, Cairo, Egypt.
omniamohamed@med.asu.edu.eg
Azza
Hassan
Department of Community, Environmental and Occupational Medicine, Faculty of
Medicine, Ain Shams University, Abbasia square, Cairo, Egypt.
drazzahassan@gmail.com
Mostafa
Shamkh
0000-0002-5521-858X
Department of Tropical Medicine, Faculty of Medicine, Ain Shams University Abbasia
square, Cairo, Egypt.
masrawy_ainshams@yahoo.com
Mahmoud
Mahmoud
Department of Chest Medicine, Faculty of Medicine, Ain Shams University, Abbasia
square, Cairo, Egypt.
mahmoudtab@yahoo.com
Ethar
Badran
Department of Tropical Medicine, Faculty of Medicine, Ain Shams University Abbasia
square, Cairo, Egypt.
ethar_badran@hotmail.com
Hany
Dabbous
Department of Tropical Medicine, Faculty of Medicine, Ain Shams University Abbasia
square, Cairo, Egypt.
drhdabbous@gmail.com
Osama
Ahmed
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Abbasia
square, Cairo, Egypt.
dr.ossamaashrafahmed@gmail.com
Rana
Taha
Department of Geriatric Medicine and Gerontology, Faculty of Medicine, Ain Shams
University, Abbasia square, Cairo, Egypt.
rmtaha86@gmail.com
Ahmed
Sherief
Department of Tropical Medicine, Faculty of Medicine, Ain Shams University Abbasia
square, Cairo, Egypt.
ahmedfouad85@live.com
10.21608/aeji.2021.72615.1144
<strong>Background and study aim:</strong> Epidemiological data reported lower death rates of COVID-19 cases in countries with higher & recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer in COVID-19 patients & correlate it with disease severity.<br /> <strong>Patients and Method:</strong> This is a Cross-sectional study where 78 patients admitted to Ain Shams University Quarantine hospitals with positive PCR for SARS-CoV-2 were enrolled. All patients underwent quantification of serum measles IgG titer. Then classified according to the COVID-19 severity into mild, moderate and severe.<br /> <strong>Results: </strong>Measles IgG was positive in 53 patients (68%) with median of 1600 (IQR 1000-or3100), borderline in 18 patients (23%) with median 250 (IQR 200-250) and negative in seven patients (9%) with median 100 (IQR 80-120). Patients with positive measles IgG were significantly older (56±16 years) than those with negative measles IgG ( 48±15 years) (P=0.03).No significant difference was found in measles IgG titer between mild , moderate and severe COVID19 cases. Intensity of pulmonary involvement by CT chest was not correlated with measles IgG titer. The median of measles IgG titer of the ICU admitted patients and those who were not, was 1150 (IQR=600-3500) and 1050 (IQR=200-1800) respectively (p=0.46). No difference in measles IgG titer between patients who recovered or died.<br /> <strong>Conclusion: </strong>Severity of COVID-19 disease and its outcome seem to be unaffected by measles IgG titer.
SARS-COV2,COVID-19 pandemic,Measles IgG
https://aeji.journals.ekb.eg/article_191420.html
https://aeji.journals.ekb.eg/article_191420_0b0517cc11e58c48b8498d5a6755c14b.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
11
3
2021
09
01
Strongyloidiasis as a Hidden Cause of Protein Losing Enteropathy
314
317
EN
Moustafa
HA
Elshamy
Department of Tropical Medicine, Faculty of Medicine, Zagazig University,Egypt.
Taghrid
M
Mahmoud
Department of Tropical Medicine, Faculty of Medicine, Zagazig University,Egypt.
tagkomy@gmail.com
Marwa
M
Ayesh Othman
Department of Tropical Medicine, Faculty of Medicine, Zagazig University,Egypt.
10.21608/aeji.2021.191427
Parasitic infection still surprises us with amazing case presentation every now and then. Intestinal nematode infection is a worldwide health problem especially in humid and hot areas. <em>Strongyloides stercoralis (S. stercoralis)</em> is a common soil- transmitted nematode infection in tropics and subtropics. Its severity ranges from asymptomatic infection in immunocompetent patients to hyperinfection and even disseminated infection in immunocompromised patients. Here, we report a case of severe protein losing enteropathy caused by<em> S. stercoralis.</em>
strongyloidiasis,Protein Losing Enteropathy
https://aeji.journals.ekb.eg/article_191427.html
https://aeji.journals.ekb.eg/article_191427_92ccef45bbac36c843ac52e5b9ce170d.pdf