Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
6
4
2016
12
01
Dickkopf-1: As a Diagnostic and Prognostic Serum Marker for Hepatocellular Carcinoma
156
165
EN
Ahmed
Sharaf
Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt
El-Said
El-Badrawy
Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt
Naglaa
Khalifa
Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt
Sameh
Abdel Monem
Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt
drsameh154@yahoo.com
Hosam
Dawod
Tropical Medicine Department, Faculty of Medicine, Zagazig University, Egypt
10.21608/aeji.2016.9974
<strong>Background and study aim:</strong> Hepatocellular carcinoma (HCC) accounts for 70 - 80% of all liver cancers and the 5-year survival is only 3 - 5%. This bad prognosis is due to the lack of an effective method for early diagnosis. So, only 30 - 40% of patients with HCC are suitable for curative treatments at the time of diagnosis. Thus, there is a great need for tools to diagnose HCC early especially in cirrhotic patients. The aim of this work is to assess the validity of serum DKK1 as a diagnostic marker for HCC and to assess prognostic value of serum DKK1 in predicting treatment response, complication and survival in HCC patients.
<strong>Patients and Methods:</strong> This study included Session [CurrentTestPartID] Patients divided into two groups. Group A: consisted of 30 patients with post hepatitic C and/or B liver cirrhosis. Group B: consisted of 30 patients with HCC on top of post hepatitic C and/or B liver cirrhosis. Group B patients underwent either radiofrequency ablation or ethanol injection. Clinical assessment, routine laboratory evaluation, CT studies and measurement of serum alpha-fetoprotein (AFP) and DKK1 were performed to all patients and repeated to group B patients 1 and 3 months after treatment.
<strong>Results:</strong> The optimum cut off value of DKK1 for diagnosis of HCC was 4.3 ng/mL (AUC 0.89, sensitivity 66.7% and specificity 96.6%) (P<0.001). While, the optimum cut off value for AFP was > 101 ng/mL with 90% sensitivity and 75.9% specificity (p<0.001). Testing of both DKK1 and AFP increased the diagnostic accuracy for HCC (AUC 0.901, sensitivity 93.3%, and specificity 75.9) (P<0.001). Serum DKK1 level significantly decreases after HCC treatment with either radio-frequency ablation or ethanol injection (P<0.001).
<strong>Conclusion:</strong> Testing of both DKK1 and AFP significantly increased the diagnostic accuracy for HCC. Meanwhile, DKK1 can be used alone for HCC diagnosis even in HCC with inconclusive AFP. DKK1 has a promising prognostic value and can be used for follow up of HCC patients who underwent loco-regional treatment.
Dickkopf-1,alpha-feto protein,Hepatocellular carcinoma
https://aeji.journals.ekb.eg/article_9974.html
https://aeji.journals.ekb.eg/article_9974_dafdb33ba369628ab94e3b4f22e1cb9d.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
6
4
2016
12
01
Monocyte Chemotactic Protein-1 Gene Expression in Blood and Ascitic Fluid of Cirrhotic Patients with Spontaneous Bacterial Peritonitis
166
174
EN
Maha
Omar
Department of Hepatology ,Gastroenterology and Infectious Diseases, faculty of Medicine, Benha University , Egypt
mahazeinelabedin@yahoo.com
Shuzan
A
Mohammed
Department of Medical Biochemistry, Faculty of Medicine, Benha University, Egypt
10.21608/aeji.2016.9976
<strong>Background and study aim:</strong> Cirrhotic patients with ascites show a higher susceptibility to bacterial infections, monocyte chemotactic protein-1 (MCP-1) secretion is up-regulated during chronic hepatitis and correlates with the severity of hepatic inflammation. The aim of this work is to determine the level of expression of MCP-1 gene in blood and ascitic fluid in cirrhotic patients with and without spontaneous bacterial peritonitis (SBP) to evaluate its role in pathogenesis of SBP and its role in diagnosis.
<strong>Patients and Methods:</strong> This study included 15 healthy subjects served as control group in addition to 35 cirrhotic patients due to HCV infection with ascites; classified into two groups, cirrhosis without SBP (15 patients) and cirrhosis with SBP (20 patients). All groups were subjected to quantitative estimation of MCP-1 gene expression in blood by real time PCR. In SBP and non SBP groups the gene expression were assessed in ascitic fluid also at diagnosis and reassessed in SBP group after treatment.
<strong>Results:</strong> Blood and ascitic fluid expression of MCP-1 gene were significant higher in SBP group than non SBP group and control group. SBP group showed a significant decrease in level of MCP-1 gene expression in blood and ascitic fluid after resolution of infection by appropriate treatment of SBP.
<strong>Conclusion:</strong> MCP-1 gene expression in both blood and ascitic fluid may be related to pathophysiology and course of SBP and can be used as a marker for diagnosis.
SBP,MCP-1,Gene expression,Cirrhosis
https://aeji.journals.ekb.eg/article_9976.html
https://aeji.journals.ekb.eg/article_9976_d749ec688dec4e739a4c478127fae48b.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
6
4
2016
12
01
Prednisolone can Prevent Post-Herpetic Neuralgia in Post-Kidney Transplant Recipient
175
179
EN
Mohammad
Ahmed
Saraya
Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
mdsaraya@yahoo.com
Mariam
Abdulrhman
Al-Fadhli
Department of Medicine, Infectious Disease Hospital, Ministry of Health, Kuwait.
medicine209@gmail.com
Jafar
Abdulrida
Qasem
Department of Applied Medical Sciences, College of Health Sciences, Public Authority for Applied Education and Training, (PAAET)
10.21608/aeji.2016.9977
<strong>Background and study aim:</strong> Post-herpetic neuralgia (PHN) is a neuropathic painful condition that is one of the most frequent complications of an acute herpes zoster infection. Till now, there is no general agreement on the definition of PHN. Some studies described a wide range of definitions, including any pain that comes after disappearing of the herpes zoster rash, whereas other studies applied the definition of pain that persist for more than one or two months after the onset of rash. The aim of this study was to assess the effect of oral prednisolone with antiviral therapy on prevention of post-herpetic neuralgia in post-kidney transplant recipient.
<strong>Patients and methods:</strong> 40 patients were divided into two groups, the first one (group A) involved 20 patients who had renal transplant within the past five years and have received oral prednisolone (10 mg/day) and the second one (group B) involved also 20 patients but they are immune-competent without co-morbidity. Follow up was done at one, three and six months to assess the pain.
<strong>Results:</strong> At time of admission and discharge, there was significant difference between group A and group B as regard zoster pain. The same significance was observed between two groups during follow up after one and three months and not observed after six months.
<strong>Conclusion:</strong> Oral corticosteroid can promote modest benefits in decreasing the pain of herpes zoster and the incidence of PHN in post-kidney transplant recipient.
Kuwait,Prednisolone,herpes zoster,post herpetic neuralgia
https://aeji.journals.ekb.eg/article_9977.html
https://aeji.journals.ekb.eg/article_9977_23077094b3e27f54bc4daed5413e94a5.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
6
4
2016
12
01
Case Report 1 :Guillain Barré Syndrome Post Primary Varicella Infection
180
181
EN
Mariam
Abdulrhman
Al-Fadhli
Department of Medicine, Infectious Disease Hospital, Ministry of Health, Kuwait.
medicine209@gmail.com
Saroj
Bala
Grover
Department of Medicine, Infectious Diseases Hospital, Kuwait
Mohamed
Ahmed
Saraya
Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
10.21608/aeji.2016.9979
<span>Guillain-Barré syndrome (GBS) is a critical condition that usually arises as a late complication of certain infections. Varicella zoster is (VZ) an extraneous antecedent infection that can cause GBS. We report a rare case of GBS following primary VZV infection in an adult.</span>
Guillain-Barré syndrome,Varicella zoster,IV immunoglobulin
https://aeji.journals.ekb.eg/article_9979.html
https://aeji.journals.ekb.eg/article_9979_0b889b0307152d9fc3b846a639bb7f13.pdf
Zagazig University, Faculty of Medicine, Endemic and Tropical Medicine Department
Afro-Egyptian Journal of Infectious and Endemic Diseases
2090-7613
2090-7184
6
4
2016
12
01
Case Report 2 :Rabies Through Organ Transplant
182
184
EN
Mariam
Abdulrhman
Al-Fadhli
Department of Medicine, Infectious Disease Hospital, Ministry of Health, Kuwait.
medicine209@gmail.com
Saroj
Bella
Grover
Department of the Medicine, Infectious Diseases Hospital, Kuwait
Mohamed
Ahmed
Saraya
Department of Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
10.21608/aeji.2016.9980
<span>The rabies virus causes fatal encephalitis and can be transmitted through tissue or organ transplantation. In March 2015, a kidney recipient with no reported exposures to potentially rabid animals died from rabies after transplantation.</span>
rabies,Transmission,recipient,infectious
https://aeji.journals.ekb.eg/article_9980.html
https://aeji.journals.ekb.eg/article_9980_840b6101fd042de82d485cf6eb8e2440.pdf