A new study in this issue of the Afro-Egyptian journal of infectious and endemic diseases investigated the use of the PAPAS score (Platelet/Age/ Phosphatase/AFP/AST) for predicting EVs in HCV-related cirrhotic patients. This study included patients at different stages of cirrhosis (compensated and decompensated) who underwent screening EGD to detect the presence of EVs. The PAPAS score and other non-invasive scores (APRI, FIB4, Lok Scor) were calculated and compared their accuracy in predicting the development of EVs. The results of this study showed that patients with EVs have a significantly higher PAPAS score than those without EVs. The PAPAS index showed higher diagnostic accuracy than the other tests (APRI, FIB-4, and Lok Score). PAPAS index AUCs were 0.939 for diagnosis of EVs with 86% sensitivity, 93.33% specificity, 95.2% PPV, 73.7% NPV, and AUC 0.746 for detecting Large EVs with 94.87% sensitivity, 86.43% specificity, 71.2% PPV, 86.7% NPV, indicating its usefulness in identifying patients with large varices who require endoscopy.